解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The beta-defensin gene cluster (DEFB) at chromosome 8p23.1 is one of the most copy number (CN) variable regions of the human genome. Whereas individual DEFB CNs have been suggested as independent genetic risk factors for several diseases (e.g. psoriasis and Crohn's disease), the role of multisite sequence va...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-252
更新日期:2010-04-19 00:00:00
abstract:BACKGROUND:Due to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by early effective treatment is the key for prognosis improvement. So far, little is known about the gene expression changes in the early stage of this serious illness. Identification of the genes related to the very ear...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-240
更新日期:2010-04-15 00:00:00
abstract:BACKGROUND:Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor alpha (TNFalpha) induces PGE2 synthesis in gingival fibroblasts. In this s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-241
更新日期:2010-04-15 00:00:00
abstract:BACKGROUND:The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism. Here we have explored the underlying reorganization of the metabolome by combining computational predictions based on constrain...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-202
更新日期:2010-03-26 00:00:00
abstract:BACKGROUND:Natural accessions of Arabidopsis thaliana are characterized by a high level of phenotypic variation that can be used to investigate the extent and mode of selection on the primary metabolic traits. A collection of 54 A. thaliana natural accession-derived lines were subjected to deep genotyping through Singl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-188
更新日期:2010-03-20 00:00:00
abstract:BACKGROUND:Understanding syntentic relationship between two species is critical to assessing the potential for comparative genomic analysis. Common bean (Phaseolus vulgaris L.) and soybean (Glycine max L.), the two most important members of the Phaseoleae legumes, appear to have a diploid and polyploidy recent past, re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-184
更新日期:2010-03-18 00:00:00
abstract:BACKGROUND:The diversity of placental architectures within and among mammalian orders is believed to be the result of adaptive evolution. Although, the genetic basis for these differences is unknown, some may arise from rapidly diverging and lineage-specific genes. Previously, we identified 91 novel lineage-specific tr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-161
更新日期:2010-03-09 00:00:00
abstract:BACKGROUND:With its genome sequence and other experimental attributes, Populus trichocarpa has become the model species for genomic studies of wood development. Wood is derived from secondary growth of tree stems, and begins with the development of a ring of vascular cambium in the young developing stem. The terminal r...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-150
更新日期:2010-03-04 00:00:00
abstract:BACKGROUND:Higher crustaceans (class Malacostraca) represent the most species-rich and morphologically diverse group of non-insect arthropods and many of its members are commercially important. Although the crustacean DNA sequence information is growing exponentially, little is known about the genome organization of Ma...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-141
更新日期:2010-02-26 00:00:00
abstract:BACKGROUND:Protein phosphorylation is responsible for a large portion of the regulatory functions of eukaryotic cells. Although the list of sequenced genomes of filamentous fungi has grown rapidly, the kinomes of recently sequenced species have not yet been studied in detail. The objective of this study is to apply a c...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-133
更新日期:2010-02-24 00:00:00
abstract:BACKGROUND:Grass carp (Ctenopharyngodon idella) belongs to the family Cyprinidae which includes more than 2000 fish species. It is one of the most important freshwater food fish species in world aquaculture. A linkage map is an essential framework for mapping traits of interest and is often the first step towards under...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-135
更新日期:2010-02-24 00:00:00
abstract:BACKGROUND:To understand gene expression networks leading to functional properties of the soybean seed, we have undertaken a detailed examination of soybean seed development during the stages of major accumulation of oils, proteins, and starches, as well as the desiccating and mature stages, using microarrays consistin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-136
更新日期:2010-02-24 00:00:00
abstract:BACKGROUND:Tandem mass spectrometry (MS/MS) has become a standard method for identification of proteins extracted from biological samples but the huge number and the noise contamination of MS/MS spectra obstruct swift and reliable computer-aided interpretation. Typically, a minor fraction of the spectra per sample (mos...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S1-S13
更新日期:2010-02-10 00:00:00
abstract:BACKGROUND:A sense-antisense gene pair (SAGP) is a gene pair where two oppositely transcribed genes share a common nucleotide sequence region. In eukaryotic genomes, SAGPs can be organized in complex sense-antisense architectures (CSAGAs) in which at least one sense gene shares loci with two or more antisense partners....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S1-S9
更新日期:2010-02-10 00:00:00
abstract:BACKGROUND:gammadelta T cells differ from alphabeta T cells with regard to the types of antigen with which their T cell receptors interact; gammadelta T cell antigens are not necessarily peptides nor are they presented on MHC. Cattle are considered a "gammadelta T cell high" species indicating they have an increased pr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-100
更新日期:2010-02-09 00:00:00
abstract:BACKGROUND:In many eukaryotes, microRNAs (miRNAs) bind to complementary sites in the 3'-untranslated regions (3'-UTRs) of target messenger RNAs (mRNAs) and regulate their expression at the stage of translation. Recent studies have revealed that many miRNAs are evolutionarily conserved; however, the evolution of their t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-101
更新日期:2010-02-09 00:00:00
abstract:BACKGROUND:Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease which causes great economic losses worldwide. Many virulence factors are involved in the pathogenesis, namely capsular polysaccharides, RTX toxins, LPS and many iron acquisition systems. In order to ide...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-98
更新日期:2010-02-08 00:00:00
abstract:BACKGROUND:Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain. RESULTS:We have used array comparative genomic hybridization (aCGH)...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-62
更新日期:2010-01-25 00:00:00
abstract:BACKGROUND:Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems. Present experimental studies typically use SNP arrays with hundreds of thousa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-58
更新日期:2010-01-22 00:00:00
abstract:BACKGROUND:Malaria is the most important parasitic disease in the world with approximately two million people dying every year, mostly due to Plasmodium falciparum infection. During its complex life cycle in the Anopheles vector and human host, the parasite requires the coordinated and modulated expression of diverse s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-34
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:The approaches for shotgun-based sequencing of vertebrate genomes are now well-established, and have resulted in the generation of numerous draft whole-genome sequence assemblies. In contrast, the process of refining those assemblies to improve contiguity and increase accuracy (known as 'sequence finishing')...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-21
更新日期:2010-01-11 00:00:00
abstract:BACKGROUND:In most species of mammals, the TRB locus has the common feature of a library of TRBV genes positioned at the 5'- end of two in tandem aligned D-J-C gene clusters, each composed of a single TRBD gene, 6-7 TRBJ genes and one TRBC gene. An enhancer located at the 3'end of the last TRBC and a well-defined promo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-3
更新日期:2010-01-04 00:00:00
abstract:BACKGROUND:Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases of wheat (Triticum aestivum L.) worldwide. In spite of its agricultural importance, the genomics and genetics of the pathogen are poorly characterized. Pst transcripts from urediniospores and germinated ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-626
更新日期:2009-12-23 00:00:00
abstract:BACKGROUND:Aspartic proteases are known to play an important role in the biology of nematode parasitism. This role is best characterised in blood-feeding nematodes, where they digest haemoglobin, but they are also likely to play important roles in the biology of nematode parasites that do not feed on blood. In the pres...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-611
更新日期:2009-12-16 00:00:00
abstract:BACKGROUND:Human genetic variation produces the wide range of phenotypic differences that make us individual. However, little is known about the distribution of variation in the most conserved functional regions of the human genome. We examined whether different subsets of the conserved human genome have been subjected...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-614
更新日期:2009-12-16 00:00:00
abstract:BACKGROUND:The reconstruction of gene regulatory networks from high-throughput "omics" data has become a major goal in the modelling of living systems. Numerous approaches have been proposed, most of which attempt only "one-shot" reconstruction of the whole network with no intervention from the user, or offer only simp...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-S3-S17
更新日期:2009-12-03 00:00:00
abstract:BACKGROUND:The steady-state behaviour of gene regulatory networks (GRNs) can provide crucial evidence for detecting disease-causing genes. However, monitoring the dynamics of GRNs is particularly difficult because biological data only reflects a snapshot of the dynamical behaviour of the living organism. Also most GRN ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-S3-S26
更新日期:2009-12-03 00:00:00
abstract:BACKGROUND:A disease-causing mutation refers to a heritable genetic change that is associated with a specific phenotype (disease). The detection of a mutation from a patient's sample is critical for the diagnosis, treatment, and prognosis of the disease. There are numerous databases and applications with which to archi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-S3-S35
更新日期:2009-12-03 00:00:00
abstract:BACKGROUND:Mammalian genomes contain a large number (approximately 1000) of olfactory receptor (OR) genes, many of which (20 to 50%) are pseudogenes. OR gene transcription is not restricted to the olfactory epithelium, but is found in numerous tissues. Using microarray hybridization and RTqPCR, we analyzed the mRNA pro...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-572
更新日期:2009-12-02 00:00:00
abstract:BACKGROUND:Various cancer cells, including those of colorectal cancer (CRC), release microvesicles (exosomes) into surrounding tissues and peripheral circulation. These microvesicles can mediate communication between cells and affect various tumor-related processes in their target cells. RESULTS:We present potential r...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-556
更新日期:2009-11-25 00:00:00
abstract:BACKGROUND:Carboxylesterase is a multifunctional superfamily and ubiquitous in all living organisms, including animals, plants, insects, and microbes. It plays important roles in xenobiotic detoxification, and pheromone degradation, neurogenesis and regulating development. Previous studies mainly used Dipteran Drosophi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-553
更新日期:2009-11-24 00:00:00
abstract:BACKGROUND:Aggressive behaviour is an important aspect in the daily lives of animals living in groups. Aggressive animals have advantages, such as better access to food or territories, and they produce more offspring than low ranking animals. The social hierarchy in chickens is measured using the 'pecking order' concep...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-544
更新日期:2009-11-19 00:00:00
abstract:BACKGROUND:The understanding of the biological function, regulation, and cellular interactions of the yeast genome and proteome, along with the high conservation in gene function found between yeast genes and their human homologues, has allowed for Saccharomyces cerevisiae to be used as a model organism to deduce biolo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-524
更新日期:2009-11-15 00:00:00
abstract:BACKGROUND:Microarray-based Comparative Genomic Hybridisation (CGH) has been used to assess genetic variability between bacterial strains. Crucial for interpretation of microarray data is the availability of a reference to compare signal intensities to reliably determine presence or divergence each DNA fragment. Howeve...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-522
更新日期:2009-11-13 00:00:00
abstract:BACKGROUND:The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT). The method is built on two information-theoretic metrics, the k-way interaction inf...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-509
更新日期:2009-11-04 00:00:00
abstract:BACKGROUND:New and improved antimicrobial countermeasures are urgently needed to counteract increased resistance to existing antimicrobial treatments and to combat currently untreatable or new emerging infectious diseases. We demonstrate that computational comparative genomics, together with experimental screening, can...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-501
更新日期:2009-10-29 00:00:00
abstract:BACKGROUND:Several global transcriptomic and proteomic approaches have been applied in order to obtain new molecular insights on skeletal myogenesis, but none has generated any specific data on glycogenome expression, and thus on the role of glycan structures in this process, despite the involvement of glycoconjugates ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-483
更新日期:2009-10-20 00:00:00
abstract:BACKGROUND:The development of second generation sequencing methods has enabled large scale DNA variation studies at moderate cost. For the high throughput discovery of single nucleotide polymorphisms (SNPs) in species lacking a sequenced reference genome, we set-up an analysis pipeline based on a short read de novo seq...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-479
更新日期:2009-10-16 00:00:00
abstract:BACKGROUND:Glandular trichomes produce a wide variety of commercially important secondary metabolites in many plant species. The most prominent anti-malarial drug artemisinin, a sesquiterpene lactone, is produced in glandular trichomes of Artemisia annua. However, only limited genomic information is currently available...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-465
更新日期:2009-10-09 00:00:00
abstract:BACKGROUND:The globe artichoke (Cynara cardunculus var. scolymus L.) is a significant crop in the Mediterranean basin. Despite its commercial importance and its both dietary and pharmaceutical value, knowledge of its genetics and genomics remains scant. Microsatellite markers have become a key tool in genetic and genom...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-454
更新日期:2009-09-28 00:00:00